What does Matthew 12:46-50 mean?

46 While he yet talked to the people, behold, his mother and his brethren stood without, desiring to speak with him. 47 Then one said unto him, Behold, thy mother and thy brethren stand without, desiring to speak with thee. 48 But he answered and said unto him that told him, Who is my mother? and who are my brethren? 49 And he stretched forth his hand toward his disciples, and said, Behold my mother and my brethren! 50 For whosoever shall do the will of my Father which is in heaven, the same is my brother, and sister, and mother. (Matthew 12:46-50 KJV)

William Burkitt’s Commentary

Observe here, 1. The verity of Christ’s human nature; he had affinity and consanguinity with men, persons near in blood to him, called his brethren, that is, his cousin-germans.

2. That the holy virgin herself was not wholly free from failings and infirmities; for here she does untimely and unseasonably interrupt our Saviour when preaching to the people, and employed about his Father’s business.

3. That Christ did not neglect his holy mother, nor disregard his near relations; only showed that he preferred his Father’s service before them.

Learn, 4. How dear believers are to Jesus Christ; he prefers his spiritual kindred before his natural. Alliance in faith, and spiritual relation to Christ, is much nearer and dearer than alliance by blood: to bear Christ in the heart is much better than to bear him in the womb.

Blessed be God, this greatest privilege is not denied to us even now: though see Christ we cannot, yet love him we may; his bodily presence cannot be enjoyed by us, but his spiritual presence is not denied us. Though Christ be not ours, in house, in arms, in affinity, in consanguinity, yet in heart, in faith, in love, in service, he is or may be ours.

Verily, spiritual regeneration brings men into a more honourable relation to Christ than natural generation ever did. Whosoever shall do the will of my Father, he is my brother, and sister, and mother.