What does Luke 8:19-21 mean?

19 Then came to him his mother and his brethren, and could not come at him for the press. 20 And it was told him by certain which said, Thy mother and thy brethren stand without, desiring to see thee. 21 And he answered and said unto them, My mother and my brethren are these which hear the word of God, and do it. (Luke 8:19-21 KJV)

William Burkitt’s Commentary

Two things are here observable, 1. The truth and verity of Christ’s human nature: he had affinity and consanguinity with men, persons near in blood to him, by the mother’s side, called here his kinsmen.

Observe, 2. That Christ’s spiritual kindred were much dearer to him than his natural.

Alliance by faith is more valued by Christ, than alliance by blood: to bear Christ in the heart is greater honor than to carry him in the womb. Blessed be God, this great and gracious privilege is not denied us even now.

Although we cannot see Christ, yet love him we may, his bodily presence cannot be enjoyed by us, but his spiritual presence is not denied to us. Though Christ be not ours in house, in arms, in affinity, and consanguinity, yet in heart, in faith, in love, and service, he is or may be ours.

Verily spiritual regeneration brings men into a more honorable relation to Christ than natural generation ever did. O how dear are obedient Christians to Christ! He prefers them in esteem before those of his own flesh and blood. My brethren are these which hear the word of God, and do it.